CICA site cookies. We use cookies in our site to offer you the best web experience. Please accept usage of cookies pressing the button.

Accept cookies

EXPRELA

Research Group

Header 002

Regulation of Gene Expression and Applications

Area: Biotechnology
Coordinator: M.ª Esperanza Cerdán Villanueva
Members

EXPRELA is a research group with a long track record in biochemistry and molecular biology. The different abilities developed by the group’s members enable the application of multidisciplinary approaches to solve research challenges with industrial and biomedical applications.

The basic research topics of interest for this group are related to the control of gene expression, with special emphasis on transcription factors, their structure, interactions with DNA, post-translational modifications and interactomes. This basic understanding has also been applied to the development of biological tools for the expression of proteins of interest using micro-organisms as cell factories. Outstanding among these research lines with a biotechnological application is the achievement of new, stable enzymes with a high catalytic capacity under industrial conditions.

The research projects under way or newly emerging are:

  1. Yeast proteins with HMG domains and their role in transcriptional regulation. Structural aspects of several HMG domains and their functional role in transcriptional regulation are studied using Saccharomyces cerevisiae and Kluyveromyces lactis yeasts as eukaryotic models.
  2. The interactome of HMGB proteins for understanding cancer of the ovaries and prostate. This project studies the proteins interacting with HMGB1 and HMGB2 and their implications in the drift of ovarian and prostate cells towards malignancy. Consideration is also given to their role in the resistance developed to platinum compounds used in chemotherapy.
  3. Fungi and thermophiles as a source of robust hydrolases of industrial interest. The evolution of the enzymes isolated from fungi by protein engineering and metagenomic techniques applied to organisms living in thermal waters are used to identify and improve new enzymes.
  4. The use of whey derived from cheese production for new uses in the production of biofuels. Synthetic biology and metabolic engineering of strains of Kluyveromyces capable of using lactose to produce biobutanol.

Este grupo de investigación participa en el Programa Oficial de Doctorado en "Biotecnología Avanzada"

Members

Coordinator

Thumb foto exprela
M.ª Esperanza Cerdán Villanueva
88101 5578

Catedrática de Universidad
Área de Bioquímica y Biología Molecular - Departamento de Biología Celular y Molecular

Staff

Aída Inés Barreiro Alonso
Investigador/a
88101 5578
Investigador/a 88101 5578
Manuel Becerra Fernández PDI 88101 5578
María Cámara Quílez
Investigador/a
88101 5578
Investigador/a 88101 5578
Juan José Escuder Rodríguez
Investigador/a
88101 5578
Investigador/a 88101 5578
María Isabel González Siso PDI 88101 5578
Mónica Lamas Maceiras PDI 88101 5578
Agustín Rico Díaz
Investigador/a
88101 5578
Investigador/a 88101 5578
María Esther Rodríguez Belmonte PDI 88101 5578
Martín Salamini Montemurri
Investigador/a
88101 5578
Investigador/a 88101 5578
Ángel Vizoso Vázquez
Investigador/a
88101 5578
Investigador/a 88101 5578
Mª Eugenia de Castro de Antonio
Investigador/a
88101 5578
Investigador/a 88101 5578
María Efigenia Álvarez Cao
Investigador/a
88101 5578
Investigador/a 88101 5578